What is low renin essential hypertension?

What is low renin essential hypertension?

Low-renin hypertension (LREH) accounts for an important subset of the hypertensive human population and is associated with salt-sensitivity and diuretic response and is also common in black patients. An interesting finding in LREH is the presence of normal plasma aldosterone levels.

Can low renin cause hypertension?

Angiotensin II is a potent vasoconstrictor and acts on the angiotensin receptors. Both high as well as low levels of renin may be associated with hypertension.

How common is low renin hypertension?

LRH is a common condition, accounting for 20 to 30% of all hypertensive patients and includes the most frequent essential form and a number of secondary and genetic subtypes.

What happens if your renin is low?

When your blood pressure drops too low or your body doesn’t have enough salt, renin gets sent into your bloodstream. That triggers a chain reaction that creates a hormone called angiotensin and signals your adrenal glands to release another hormone called aldosterone.

What does a low aldosterone renin ratio mean?

Most often, your renin test results will be compared with aldosterone test results. These results may show one of the following: Lower than normal renin/Lower than normal aldosterone. This may mean you have Cushing’s syndrome, a disorder in which the adrenal glands make too much of a hormone called cortisol.

How is Liddle syndrome treated?

Treatment. Treatment for Liddle syndrome consists of following a low sodium diet and taking potassium-sparing diuretics, which reduce blood pressure and correct hypokalemia and metabolic alkalosis. Conventional anti-hypertensive therapies are not effective for this condition.

How do you treat low renin levels?

Renal hypertension (high renin/high aldosterone) is best treated with angiotensin receptor antagonists; primary aldosteronism (low renin/high aldosterone) is best treated with aldosterone antagonists (spironolactone or eplerenone); and hypertension due to overactivity of the renal epithelial sodium channel (low renin/ …

What does low renin and low aldosterone mean?

What does a lack of aldosterone do to blood pressure?

Low aldosterone levels are found in a rare condition called Addison’s disease. In Addison’s disease, there is a general loss of adrenal function resulting in low blood pressure, lethargy and an increase in potassium levels in the blood (see the article on Addison’s disease for further information).

What are the symptoms of low aldosterone?

Signs and symptoms may include:

• Extreme fatigue.
• Weight loss and decreased appetite.
• Darkening of your skin (hyperpigmentation)
• Low blood pressure, even fainting.
• Salt craving.
• Low blood sugar (hypoglycemia)
• Nausea, diarrhea or vomiting (gastrointestinal symptoms)
• Abdominal pain.

Is Liddle syndrome fatal?

Some people with Liddle syndrome have no additional signs or symptoms, especially in childhood. Over time, however, untreated hypertension can lead to heart disease or stroke , which may be fatal. In addition to hypertension, affected individuals can have low levels of potassium in the blood (hypokalemia).